1. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts. Hydrophilic suppository bases also melt at body temperature, and … •A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. When suppository mixtures and bases cool, they contract. 6. They come in different shapes and sizes, but they are usually narrowed at … The selection of a suppository base is dependent upon a number of physicochemical variables, including the solubility characteristics of the drug. https://www.thefreedictionary.com/Suppository+bases, A small plug of medication designed to melt at body temperature within a body cavity other than the mouth, especially the rectum or vagina. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. The shape, volume and consistency of suppositories are suitable for rectal application. A suppository is a medication that is inserted into the rectum, vagina, or urethra to be broken down and absorbed by the body. Also called. A suppository, which is a general term for a solid dose of medicine that is inserted into the anus or the vagina, can contain different medications, from contraceptives to medication to kill off yeast infections. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Suppository bases usually employed are cocoa butter, glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of PEG (15). suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease Based on WordNet 3.0, Farlex clipart collection. Learn more. This is then poured into the mold, refrigerated to harden, cut into pieces the size of the patient's pinky finger, and inserted as needed. Such a hole is undesirable. It is suitable for use with a wide range of medicaments including alkaloids, boric acid, and zinc oxide. Specifications for Suppository Bases 1 Origin & Chemical Composition: A brief description of the composition of the base reveals the sours of the origin (natural or synthetic or modified natural products). Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. 2. Glycerinated Gelatin is a useful suppository base, particularly for vaginal suppositories. Water-soluble bases dissolve in rectal fluids and Tableted suppositories or inserts. Base, in chemistry, any substance that in water solution is slippery to the touch, tastes bitter, changes the color of indicators (e.g., turns red litmus paper blue), reacts with acids to form salts, and promotes certain chemical reactions (base catalysis). . Learn more. A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. Some mixtures and bases have very pronounced contractions (e.g., cocoa butter, PEG) while others have much smaller ones (e.g., glycerinated gelatin, MBK®). C. Emulsifying bases. As the warmth of your body melts the … © 2003-2012 Princeton University, Farlex Inc. supposition meaning: 1. the fact of believing something is true without any proof or something that you believe to be…. Suppositive definition, of the nature of or involving supposition; suppositional. Definition of suppository : a solid but readily meltable cone or cylinder of usually medicated material for insertion into a bodily passage or cavity (such as the rectum) Examples of suppository in a Sentence Glycerinated Gelatin Polyethylene Glycols. C. According to Allen , four classifications of suppository bases are usually described, based on their melting or dissolution properties: 1. A small, solid body shaped for ready introduction into one of the orifices of the body other than the oral cavity (e.g., rectum, urethra, vagina), made of a substance, usually medicated, that is solid at ordinary temperatures but melts at body temperature. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API. 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